Describe how mutations could lead to drug resistance in. Researchers have discovered a mechanism of resistance to checkpoint inhibitors and how to reverse it. Fortunately, if you do develop a resistance, numerous. In this passionate, affecting documentary, alanis obomsawin a member of the abenaki tribe describes the 11week. Measuring plasma pcsk9 may id resistance to pcsk9 inhibitors. Study identifies potential marker of parp inhibitor resistance. Summary of herbicide mechanism of action according to the. These drugresistant hiv1 protease mutants also have at least one mutation in a key amino acid residue positioned directly in one of. Chandler although there are several tales of slaves revolting against their masters in the annals of history, the overthrow of the creole by captives heading from virginia to louisiana is one of the more riveting accounts. Titles authors contributors subjects date communities. Describe how mutations could lead to drug resistance in the rt enzyme. In july 1990,a dispute over a proposed golf course to be built on kanienkehaka mohawk. Marc glassman is the editor of pov, artistic director of pages unbound, film critic for classical 96. The incident took place when native land was taken by the white community to build a golf course.
Similarly, the findings on the effect of vpa on drug resistance are controversial. This essay discusses how the film kanehsatake deals with the european conquest of north america and its legacy. Overcoming acquired resistance to anticancer therapy. Include physical, molecular, and bioche get the answers you need, now. Mechanism of resistance in common ragweed to ppoinhibiting herbicides welcome to the ideals repository. The fact that this crisis took place before i was born is hardly an excuse as to why i have never learned about such an important event for the aboriginal peoples. A featurelength, multiaward winning documentary by a native american filmmaker set in the thick of the armed confrontation between native american mohawks and canadian government forces during the 1990 standoff in the mohawk village of kanehsatake near the village of oka in quebec. Chemical resistance of polycarbonate products at room temperature chemical chemicalconcentration resistance. Produced by the national film board of canada, the film won 18 canadian and international awards, including the distinguished documentary achievement award from the international documentary association and the city tv award for best canadian feature.
As they did a little talking, it turned out that she was alanis obomsawin, a wellregarded aboriginal american filmmaker from canada neither of us had heard of her, but i probably should have on her. The als inhibitors 126 resistant species are most prone to resistance, followed by the triazines 69 species, and the accase inhibitors 42 species. Mechanisms of resistance to kinase inhibitors and strategies to prevent the development of drug resistance kobayashi h, iwai k, niiro e, morioka s, yamada y, ogawa k and kawahara n department of obstetrics and gynecology, nara medical university, nara, japan. Most targeted anticancer therapies, as well as cytotoxic and radiation therapies, are encumbered by the development of secondary resistance by cancer cells. Healthdayplasma levels of proprotein convertase subtilisinkexin type 9 pcsk9 may help assess apparent resistance to pcsk9 inhibitors, according to. Vpa has been used for numerous years to treat epilepsy and bipolar disorders, and it is now undergoing phase iiistage clinical trials as a potent hdac inhibitor against leukemia, myelodysplasia and cervical cancer. Our first real endeavor as a class was to watch the documentary kanehsatake 270 years of resistance. Hdac inhibitorinduced drug resistance involving atp. For full quality, download the divx avi file and play it with vlc a featurelength, multiaward winning documentary by. Towards enhancing durability and efficacy of pcsk9 inhibitors first paragraph of article the 2003 discovery of proprotein convertase subtilisinkexin type9 pcsk9 a circulating protein targeting the low density lipoprotein ldl receptor for its degradation paved the way for the development of several. Kahnawake man 1997 and rocks at whiskey trench 2000. Supported by the city of toronto and the ontario media development corporation.
In july 1990, a dispute over a proposed golf course to be built on kanienkehaka mohawk lands in oka, quebec, set the stage for a historic confrontation that. Kanehsatake 270 years of resistance 1990, directed by. The chemical resistance information in this table is based on our research and experience and may be considered solely as a basis for recommendation, but not as a guarantee, unless specifically furnished as such by palram. In short the racist piece of shit mayor of oka in so called quebec, wanted to expand the local golf course by destroying a mohawk burial ground. This interactive website offers aggregated resistance data. Nastar influenza neuraminidase inhibitor resistance. Antibiotic resistance defined as microorganisms that are not inhibited by usually achievable systemic concentration of an antimicrobial agent with normal dosage schedule and or fall in the minimum inhibitory concentration mic range. The number of laboratories sending data to anresis. The twoandahalf month ordeal received brief national attention when the mohawk warriors of kahnawake, in support of their. Kanehsatake 270 years of resistance cinema politica.
Resistance is a complex phenomenon involving multiple mechanisms, including activation of signaling pathways such as phosphatidylinositol 3kinase pi3kaktmammalian target of rapamycin mtor. The mohawks confined to the community center eventually leave. Get an adfree experience with special benefits, and directly support reddit. Hiv can also become drug resistant, but most people are able to use antiretroviral combination therapy for many years without ever developing such a resistance. Mechanisms of acquired resistance to targeted cancer therapies. This documentary is an eye opening, unapologetic look at the 1990 oka crisis. Film and discussion with kim campbell former prime minister of canada kanehsatake is the awardwinning documentary film by native american filmmaker alanis obomsawin depicting the twoandahalf month armed confrontation between native american mohawks and canadian government forces. We will show the film on friday, february 28th at 10 am and 1 pm in the library instruction room. Mechanisms of acquired resistance to crizotinib have been elucidated both from drugsensitive alktranslocated cell lines selected for resistance, as. On a july day in 1990, a confrontation propelled native issues in kanehsatake and the village of oka, quebec, into the international spotlight.
Furthermore, an in vivoderived mek inhibitorresistant line also shows increased kras expression. The creole slave revolt took place on this day in 1841 comments. We see the themes of resistance and activism, as the documentary shows us the standoff at oka. This collection is made up of her films concerning the mohawk demonstrations at kanehsatake and kahnawake in 1990.
Resistance mechanism discovered for checkpoint inhibitors. Obomsawins detailed portrayal of the mohawk community places the oka crisis within the larger context of mohawk land rights dating back to 1535 when france claimed the site of presentday montreal which had been the mohawk. Nastar influenza neuraminidase inhibitor resistance assay analysis. Some features of this site may not work without it. The team also showed that, in mouse models of small cell lung cancer, inactivation of slfn11 was associated with resistance to combination therapy consisting of a parp inhibitor and the chemotherapy drug temozolomide. A role for kras in conferring resistance to the mek. They are jailed for a short time and then released. The biomarker results from the imvigor210 study are reported at the esmo immuno oncology.
In the end, there is no real resolution to the stand off. The original project idea and goals come from the community partner. Antibiotic resistance mechanism flashcards quizlet. Using this tool, you can perform data analyses for your assay outside of your browser. Screening at moma as part of the film exhibition alanis obomsawin. We confirmed a causative role for kras in conferring resistance to ci1040 by transfecting kras into parental c26 cells, whereupon an elevation in the levels of phosphorylated erk12 was observed in addition to resistance to ci1040. Resistance to pd1pdl1 checkpoint inhibition sciencedirect. Development of drug resistance to hiv1 protease inhibitors.
Alanis obomsawin has been making quality films since 1971. Particularly known for our worldclass international, avantgarde, and repertory cinema, international house philadelphias film program has been recognized by philadelphia magazine with a best of philly award for best film fun. For example, the posterchild for success in antipd1 therapy, and also the example for which clinical data are most mature, is melanoma. It was in my opinion one of the most shameful incidents in canadas last 50 years. Herbicideresistant weeds first became problematic in the usa and europe in the 1970s and early 1980s due to the repeated applications of atrazine and simazine in maize crops. The essay then ties in the notion of oppression of in our society of other groups. Kanehsatake 270 years of resistance is arguably alanis obomsawins most important film, documenting the military 1990 siege of a mohawk reserve near oka, quebec, and its causes. In 1990, a land dispute between the mohawk first nations community and the town of oka, quebecwhich planned to develop a golf course. The myassaysconfig file contains all the information necessary to perform analyses for this assay with the myassays desktop client. As previously mentioned, while highly effective, antipd1pdl1 therapies engender little to no benefit for many patients, and patients can be stratified as being sensitive, or as displaying either primary or acquired resistance. Its been almost 20 years since the oka crisis happened in the fall of 1990. Followed by a postscreening conversation with the director.
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